M7820

Monoclonal Anti-MAGE-C1

clone CT7-33, purified from hybridoma cell culture

• Sinonimo/i: Anti-CT7
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: CT7-33, monoclonal
• Forma fisica: buffered aqueous solution
• PM: antigen ~180 kDa
• Reattività contro le specie: human
• Concentrazione: ~1 mg/mL
• tecniche: immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: 1-2 μg/mL using total cell extract of SKML37 cells
• Isotipo: IgG1
• N° accesso UniProt: O60732
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... MAGEC1(9947)

Descrizione

Descrizione generale

Anti-MAGE-C1 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma CT7-33 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from mice immunized with human recombinant MAGE-C1. The first melanoma-associated antigen (MAGE) to be identified was MAGE-A1. The MAGE family of proteins contains over 25 genes that have now been identified in human. These proteins share a homologous region, named the MAGE homology domain (MHD).

MAGE family member C1 (MAGE-C1) belongs to the melanoma antigen gene (MAGE) family and consists of 1142 amino acids. The gene encoding MAGE-C1 is localized on human chromosome Xq26-27 and has four exons.

Immunogeno

human recombinant MAGE-C1.

Applicazioni

• Anti-MAGE-C1 antibody, Mouse monoclonal has been used in:
• enzyme-linked immunosorbent assay (ELISA)
• immunocytochemistry
• immunoblotting
• immunoprecipitation
• immunohistochemistry

Azioni biochim/fisiol

Although the physiological role of melanoma-associated antigen (MAGE) proteins is unknown, it has been reported that MAGE-C1 interacts and co-localizes with an additional cancer testis antigen, NY-ESO-1, in melanoma cells.

MAGE family member C1 (MAGE-C1) has been studied as the most expressed cancer or testis antigen in multiple myeloma.

Descrizione del bersaglio

MAGE-C1 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)