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I3639

Sigma-Aldrich

Isoetharine mesylate salt

Sinonimo/i:

4-[1-Hydroxy-2-[(1-methylethyl)amino]butyl]-1,2-benzenediol mesylate salt

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About This Item

Formula empirica (notazione di Hill):
C13H21NO3 · CH4O3S
Numero CAS:
7279-75-6
Peso molecolare:
335.42
Numero CE:
230-695-8
Numero MDL:
MFCD00133422
Codice UNSPSC:
12352200
ID PubChem:
24278491
NACRES:
NA.77

Ideatore

Sanofi Aventis

Temperatura di conservazione

2-8°C

Stringa SMILE

CS(O)(=O)=O.CCC(NC(C)C)C(O)c1ccc(O)c(O)c1

InChI

1S/C13H21NO3.CH4O3S/c1-4-10(14-8(2)3)13(17)9-5-6-11(15)12(16)7-9;1-5(2,3)4/h5-8,10,13-17H,4H2,1-3H3;1H3,(H,2,3,4)
SOYAGMVKMXZVNZ-UHFFFAOYSA-N

Informazioni sul gene

human ... ADRB1(153) , ADRB2(154) , ADRB3(155)

Applicazioni

Isoetharine mesylate salt has been used:
  • as an adrenergic drug to test its effect on embryo implantation in 4-day pregnant mice
  • as a substrate for recombinant human sulfotransferase (SULT) in SULT assay to monitor conjugation reaction
  • as a β-2 agonist in collision-induced dissociation (CID) mass spectrometry analysis

Azioni biochim/fisiol

Isoetharine is an agonist for β-adrenergic receptors and is a bronchodilator. It is a catecholic drug metabolized by sulfotransferases and is present in human urine and plasma as a sulfated metabolite. Catechol O-methyltransferase (COMT) also mediates the methylation of isoetharine in the metabolic conjugation pathway.

Caratteristiche e vantaggi

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302 + H312 + H332

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Aronson JK
- Pesticide Residues in Food - 1992: Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Expert Group on Pesticide Residues, Rome, 21-30 September 1992 (2016)
Gas-phase dissociation pathways of Beta-2 agonists
Carlo MJ, et al.
International Journal of Mass Spectrometry, 463, 116548-116548 (2021)
P Carvalho et al.
Journal of applied physiology (Bethesda, Md. : 1985), 84(1), 215-221 (1998-02-06)
We studied the dose-dependent effects of inhaled isoetharine HCl, a beta-adrenergic bronchodilator (2.5, 5.0, 10.0, and 20.0 mg), on bronchial blood flow (Qbr) in anesthetized sheep. Isoetharine resulted in a dose-dependent increase in Qbr. With a total dose of 17.5
Qi Chen et al.
The Journal of biological chemistry, 286(6), 4349-4356 (2010-12-15)
Pregnancy loss is a serious social and medical issue, with one important cause associated with aberrant embryo implantation during early pregnancy. However, whether and how the process of embryo implantation is affected by environmental factors such as stress-induced sympathetic activation
N B Charan et al.
Journal of applied physiology (Bethesda, Md. : 1985), 82(2), 686-692 (1997-02-01)
In anesthetized sheep, we measured bronchial blood flow (Qbr) by an ultrasonic flow probe to investigate the interaction between inhaled nitric oxide (NO; 100 parts/million) given for 5 min and 5 ml of aerosolized isoetharine (1.49 x 10(-2) M concentration).
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