D7000

Deoxycorticosterone acetate

• Sinonimo/i: 11-Deoxycorticosterone acetate, 21-Acetoxy-4-pregnene-3,20-dione, 21-Acetoxyprogesterone, 21-Hydroxy-4-pregnene-3,20-dione 21-acetate, 21-Hydroxyprogesterone 21-acetate, 4-Pregnen-21-ol-3,20-dione 21-acetate, Cortexone acetate, DOC acetate
• Formula empirica (notazione di Hill): C₂₃H₃₂O₄
• Numero CAS: 56-47-3
• Peso molecolare: 372.50
• Beilstein: 2570798
• Numero CE: 200-275-9
• Numero MDL: MFCD00003660
• Codice UNSPSC: 12352200
• ID PubChem: 24894065
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic (organic)
• Sterilità: non-sterile
• Saggio: ≥98% (HPLC)
• Stato: powder
• Solubilità: H₂O: insoluble; acetone: soluble (1 in 30); alcohol: soluble (1 in 50); chloroform: freely soluble; dioxane: slightly soluble; vegetable oils: slightly soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: room temp
• Stringa SMILE: [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@]([H])(CC[C@@]24[H])C(=O)COC(C)=O
• InChI: 1S/C23H32O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h12,17-20H,4-11,13H2,1-3H3/t17-,18-,19-,20+,22-,23-/m0/s1; VPGRYOFKCNULNK-ACXQXYJUSA-N
• Informazioni sul gene: human ... NR3C2(4306)

Descrizione

Descrizione generale

Deoxycorticosterone acetate is an endogenous neurosteroid found in brain and peripheral circulation, which is produced by progesterone.[1] It is both a mineralocorticoid and a glucocorticoid. It is used to treat adrenocortical insufficiency or Addison′s disease. Deoxycorticosterone acetate improves insulin sensitivity.[2] It acts as a precursor to glucocorticoid corticosterone and the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one.[1]

Applicazioni

Deoxycorticosterone acetate has been used to induce hypertensive pregnancy.[3] It has also been used to investigate the effect of low epicatechin dosing on the cardiovascular function of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.[4]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)