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C101

8-Cyclopentyl-1,3-dipropylxanthine

A1 adenosine receptor antagonist, solid

Sinonimo/i:

1,3-Dipropyl-8-cyclopentylxanthine, DPCPX, PD 116,948

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Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
25 mg
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CHF 82.80
100 mg
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CHF 181.00
CHF 153.85

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C16H24N4O2
Numero CAS:
102146-07-6
Peso molecolare:
304.39
UNSPSC Code:
12352202
PubChem Substance ID:
24277697
NACRES:
NA.77
MDL number:
MFCD00055117
Form:
solid
Quality level:
100

CHF 82.80

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Nome del prodotto

8-Cyclopentyl-1,3-dipropylxanthine, solid

form

solid

Quality Level

100

color

white

solubility

DMSO: >10 mg/mL, 0.1 M NaOH: 2 mg/mL, ethanol: 4 mg/mL, H2O: insoluble

εmax

14,800 at 276 nm in ethanol

SMILES string

CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)C3CCCC3

InChI

1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)

InChI key

FFBDFADSZUINTG-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)

Application

8-Cyclopentyl-1,3-dipropylxanthine has been used as an adenosine receptor (A1AR) antagonist in macrophages[1] and human umbilical vein endothelial cells (HUVECs).[2] It has also been used as A1AR antagonist in MCF-7 breast cancer cell line to test its anti-cancer effect.[3]

Biochem/physiol Actions

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) is a selective A1 adenosine receptor antagonist.[4] DPCPX possesses anti-cancer functionality. It induces apoptosis in breast cancer cells and favors mRNA expression of caspases.[3]

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Questo articolo
C102M2547U103
8-Cyclopentyl-1,3-dipropylxanthine solid

Sigma-Aldrich

C101

8-Cyclopentyl-1,3-dipropylxanthine

8-Cyclopentyl-1,3-dimethylxanthine ≥98% (HPLC), powder

Sigma-Aldrich

C102

8-Cyclopentyl-1,3-dimethylxanthine

8-Methoxymethyl-3-isobutyl-1-methylxanthine ≥98%

Sigma-Aldrich

M2547

8-Methoxymethyl-3-isobutyl-1-methylxanthine

U-69593 solid

Sigma-Aldrich

U103

U-69593

form

solid

form

powder

form

solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

solubility

DMSO: >10 mg/mL, ethanol: 4 mg/mL, H2O: insoluble, 0.1 M NaOH: 2 mg/mL

solubility

H2O: slightly soluble <0.28 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.77 mg/mL, DMSO: ~16 mg/mL at 60 °C, 0.1 M NaOH: soluble

solubility

ethanol: 10 mg/mL

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 10 mg/mL, 0.1 M HCl: >40 mg/mL, ethanol: >40 mg/mL, 0.1 M NaOH: insoluble, H2O: insoluble

color

white

color

white to off-white

color

-

color

white

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)

Gene Information

human ... ADORA1(134)

Gene Information

human ... PDE1A(5136), PDE1B(5153)

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
mouse ... Oprk1(18387)
rat ... Oprd1(24613), Oprk1(29335), Oprm1(25601)

εmax

14,800 at 276 nm in ethanol

εmax

-

εmax

-

εmax

-

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000557459
0000557459
0000521711
0000521710
0000521710

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Numero articolo commerciale globale

SKUGTIN
791423-250MG04061832939445
C101-25MG04061833460269
C101-25G04061832283579
C101-100MG04061832089508

Questions

  1. Qual a temperatura de armazenamento do C101?

    1 answer

    1. This product may be stored at room temperature.

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