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B8429

Sigma-Aldrich

Anti-Bax antibody, Mouse monoclonal

clone 6A7, purified from hybridoma cell culture

Sinonimo/i:

Anti-BCL2L4

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

6A7, monoclonal

Stato

buffered aqueous solution

PM

antigen 21 kDa (and possibly a dimer of 42 kDa)

Reattività contro le specie

mouse, rat, human

Concentrazione

2 mg/mL

tecniche

immunoprecipitation (IP): suitable
microarray: suitable
western blot: 10-60 μg/mL using extract of human breast adenocarcinoma MCF-7 cells, activated with dexamethasone

Isotipo

IgG1

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... BAX(581)
mouse ... Bax(12028)
rat ... Bax(24887)

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Descrizione generale

Bax is a 21kD integral organelle membrane protein that belongs to the Bcl-2 family and is expressed mainly in the mitochondria. The formation of bax homodimer accelerates apoptotic death whereas its heterodimerization with Bcl-2 or Bcl-xL can block apoptosis. Monoclonal anti-Bax antibody can be used to study the intracellular redistribution of Bax protein upon induction of apoptosis and its unique subcellular localization. This product can also be used in immunoblot analysis to estimate variations in the expression of specific proteins involved in apoptosis signalling. Mouse anti-Bax antibody reacts specifically with the epitope present within the amino acids 12-24 shared by bax from rat, mouse and human.
The B-cell lymphoma 2 (BCL2) associated X, apoptosis regulator (BAX) is mapped to human chromosome 19q13.33.

Immunogeno

synthetic peptide corresponding to amino acids 12-24 of the human Bax sequence, conjugated to KLH.

Applicazioni

Anti-Bax antibody, Mouse monoclonal has been used in the western blotting detection in human retinal pigment epithelium cell lines, glioma, and breast cancer cell lines.
Monoclonal anti-Bax antibody can be used in immunocytochemistry (diluted 1: 1500) and western blot. It is also useful in microarray and immunoprecipitation.

Azioni biochim/fisiol

Mutations in the B-cell lymphoma 2 (BCL2) associated X, apoptosis regulator (BAX) gene is implicated in colorectal cancer. BAX is associated with ovarian follicular dysfunction.

Stato fisico

Solution in phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Antitumor effects of arsenic disulfide on the viability, migratory ability, apoptosis and autophagy of breast cancer cells.
Zhao Y, et al.
Oncology Reports, 41(1), 27-42 (2019)
Ning Yang et al.
Cell death & disease, 8(2), e2587-e2587 (2017-02-06)
Delocalized lipophilic cations (DLCs) selectively accumulate in cancer cell mitochondria and have long been explored for therapeutic applications. Although targeted effects to cancer cells are demonstrated in vitro, non-specific toxicities in vivo have hampered clinical development. Identifying the molecular mechanisms
Sunny R Slone et al.
PloS one, 6(7), e21720-e21720 (2011-07-30)
Disruption of 14-3-3 function by alpha-synuclein has been implicated in Parkinson's disease. As 14-3-3s are important regulators of cell death pathways, disruption of 14-3-3s could result in the release of pro-apoptotic factors, such as Bax. We have previously shown that
Genetics of primary ovarian insufficiency: a review.
Fortuno C and Labarta E
Journal of Assisted Reproduction and Genetics, 31(12), 1573-1585 (2014)
Primary ovarian insufficiency.
De Vos M, et al.
Lancet, 376(9744), 911-921 (2010)

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