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427M-9

Sigma-Aldrich

p27Kip1 (SX53G8) Mouse Monoclonal Antibody

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100
500

Coniugato

unconjugated

Forma dell’anticorpo

culture supernatant

Tipo di anticorpo

primary antibodies

Clone

SX53G8, monoclonal

Descrizione

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Confezionamento

vial of 0.1 mL concentrate (427M-94)
vial of 0.5 mL concentrate (427M-95)
bottle of 1.0 mL predilute (427M-97)
vial of 1.0 mL concentrate (427M-96)
bottle of 7.0 mL predilute (427M-98)

Produttore/marchio commerciale

Cell Marque™

tecniche

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotipo

IgG1κ

Controllo

tonsil

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Visualizzazione

nuclear

Informazioni sul gene

rat ... Cdkn1B(83571)

Categorie correlate

Descrizione generale

p27 is a cyclin-dependent kinase inhibitor which regulates progression from G1 to S phase by binding and inhibiting cyclin-dependent kinases. Low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, small breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, lymph node metastases in Papillary carcinoma of the Thyroid, and more aggressive phenotype in carcinoma of the cervix.

Qualità


IVD
IVD
IVD
RUO

Linkage

p27Kip1 Positive Control Slides, Product No. 427S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Note legali

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Maria J Ribal et al.
Anticancer research, 23(6D), 5101-5106 (2004-02-26)
To assess the prognostic value of p27 protein expression in clinically localised prostate cancer with respect to biochemical recurrence after radical prostatectomy. Fifty-two patients (median age 63 years) with prostate cancer were treated by radical prostatectomy in an 18-month period.
Mark L C Khoo et al.
The Journal of clinical endocrinology and metabolism, 87(4), 1814-1818 (2002-04-05)
Lymph node metastasis in papillary thyroid carcinoma increases the morbidity of treatment and the risk of local regional relapse and may also affect cure rates and survival. Factors that predict lymph node metastasis are, however, unclear. We analyzed 125 patients
Mark L C Khoo et al.
Archives of otolaryngology--head & neck surgery, 128(3), 253-257 (2002-03-12)
Papillary microcarcinomas (PMCs) of the thyroid (measuring less than 1 cm in maximum dimension) are extremely common incidental histologic findings, and most of these tumors are not considered clinically significant. However, rare PMCs behave aggressively and metastasize early, giving rise
P Tan et al.
Cancer research, 57(7), 1259-1263 (1997-04-01)
Breast carcinomas < or = 1 cm in size (T1a,b) are being detected more frequently as a result of screening. Because traditional prognostic parameters are either lacking (tumor size) or rare (nodal metastases), a marker(s) is needed to identify the
V Esposito et al.
Cancer research, 57(16), 3381-3385 (1997-08-15)
Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small
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