FCMAB250A4

Milli-Mark^® Anti-Bcl-2 Antibody, Alexa Fluor^™488, clone AW604

clone AW604, Milli-Mark^®, from mouse

• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: ALEXA FLUOR^™ 488
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: AW604, monoclonal
• Reattività contro le specie: human
• Produttore/marchio commerciale: Milli-Mark^®
• tecniche: flow cytometry: suitable
• Isotipo: IgG2a
• N° accesso NCBI: NP_000624
• N° accesso UniProt: P10415
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... BCL2(596)

Descrizione

Descrizione generale

Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 also regulates cell death by controlling the mitochondrial membrane permeability and appears to function in a feedback loop system with caspases. It appears to Inhibit caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Further understanding in how Bcl-2 functions and interacts with other proteins to promote or inhibit apoptosis may lead to new treatments for cancer, neurological disorders and autoimmune diseases.

Specificità

Antibody recognizes Bcl-2.

Immunogeno

KLH-conjugated, synthetic peptide corresponding to human Bcl-2

Applicazioni

Research Category
Apoptosis & Cancer

Research Sub Category
BCL2 & Inhibition

This Milli-Mark Bcl-2 antibody is validated for use in Flow for the detection of the Milli-Mark Bcl-2 protein.

Qualità

Evaulated by flow cytometery using Jurkat cells.

Descrizione del bersaglio

26 kDa Calculated

Stato fisico

Protein G Purified

Purified mouse monoclonal IgG2a conjugated to Alexa Fluor^™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Stoccaggio e stabilità

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Risultati analitici

Control
Jurkat Cells

Note legali

ALEXA FLUOR is a trademark of Life Technologies

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Alexa Fluor^™ is a registered trademark of Molecular Probes, Inc.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable