ABN466

Anti-NANOS2 Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: Nanos homolog 2, NOS-2, NANOS2
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: rat, human
• tecniche: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• N° accesso UniProt: P60321
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... NANOS2(339345)

Descrizione

Descrizione generale

Nanos homolog 2 (NANOS2) is a zinc-finger containing, RNA-binding protein belonging to the nanos family. NANOS2 plays an important role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. It has been implicated in germ cell development in both invertebrates and vertebrates. Unlike NANOS1, whose expression in mice is dispensable, the NANOS2 and NANOS3 proteins are required for germ cell development. NANOS2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while NANOS3-null PGCs are lost during the migration stage regardless of sex.

Specificità

This antibody recognizes the N-terminus of NANOS2.

Immunogeno

KLH-conjugated linear peptide corresponding to the N-terminus of human NANOS2.

Applicazioni

Detect Nanos homolog 2 using this rabbit polyclonal antibody, Anti-NANOS2 Antibody validated for use in western blotting, IHC & Immunofluorescence.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected NANOS2 in human brain tissue.

Immunofluorescence Analysis: 20 µg/mL from a representative lot detected NANOS2 in human testis cells.

Qualità

Evaluated by Western Blotting in rat brain tissue.

Western Blotting Analysis: 2 µg/mL of this antibody detected NANOS2 in 15 µg of rat brain tissue.

Descrizione del bersaglio

~15 kDa observed

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable