QBD10011

Phthalimidooxy-dPEG^®₄-NHS ester

• Formula empirica (notazione di Hill): C₂₃H₂₈N₂O₁₁
• Peso molecolare: 508.48
• Numero MDL: MFCD28155511
• Codice UNSPSC: 12352108
• ID PubChem: 329823874
• NACRES: NA.22

Proprietà

• Saggio: >90%
• Forma fisica: solid or viscous liquid
• Impiego in reazioni chimiche: reactivity: amine reactive; reagent type: cross-linking reagent; reactivity: thiol reactive
• Gruppo funzionale: NHS ester
• Architettura del polimero: shape: linear; functionality: heterobifunctional
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O

Descrizione

Caratteristiche e vantaggi

Phthalimidooxy-dPEG^®₄-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG^® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG^® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.

Note legali

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable