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Documenti

900671

Sigma-Aldrich

Methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)

5k-2k

Sinonimo/i:

mPEG-b-PCL, mPEG-PCL

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About This Item

Formula condensata:
CH3O(CH2CH2O)n(COCH2CH2CH2CH2CH2O)mH
Codice UNSPSC:
12162002
NACRES:
NA.23

Livello qualitativo

100

Forma fisica

powder

PM

PCL average Mn ~2,000
PEG average Mn ~5,000

Temp. transizione

flash point >230 °F
Tm 54-57 °C

Temperatura di conservazione

2-8°C

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Applicazioni

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These materials have been used as a block copolymer surfactant as well as in control release and nanoparticle formulation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

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On the mechanism of formation of vesicles from poly(ethylene oxide)-block-poly(caprolactone) copolymers.
Adams DJ, et al.
Soft Matter, 5, 3086-3096 (2009)
Xu Wen Ng et al.
Journal of pharmaceutical sciences, 103(11), 3631-3640 (2014-09-17)
Despite the success that drug-eluting stents (DESs) have achieved for minimizing in-stent restenosis (ISR), the antirestenotic agents used in DES have been implicated in delayed endothelial healing and impairment of endothelial functions. Cenderitide (CD-NP) is a novel antiproliferation chimeric peptide
Xu Wen Ng et al.
Drug delivery and translational research, 5(5), 469-479 (2015-06-24)
Timolol maleate (TM) has been used for many years for the reduction of intraocular pressure (IOP) in glaucoma patients. However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage
Simple solvothermalsynthesis of hydrophobic magnetic monodispersed Fe3O4 nanoparticles.
Liu J, et al.
Mat. Res. Bul., 48(2), 416-421 (2013)
Bhuvana S Doddapaneni et al.
Journal of controlled release : official journal of the Controlled Release Society, 220(Pt A), 503-514 (2015-11-19)
Metastatic melanoma has a high mortality rate due to lymphatic progression of the disease. Current treatment is surgery followed by radiation and intravenous chemotherapy. However, drawbacks for current chemotherapeutics lie in the fact that they develop resistance and do not
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Articoli

Polymersomes for Drug Delivery

The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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