XBP1
X-box binding protein 1
Sinonimi:
TREB5, XBP-1, XBP2
Specie:
Human XBP1 (7494), Mouse Xbp1 (22433), Rat Xbp1 (289754), Zebrafish xbp1 (140614), fruit fly Xbp1 (44226), chicken XBP1 (416918), dog XBP1 (477532), cow XBP1 (541236)
ID UniProtKB:
ID gene:
- Human(7494) Summary: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
- Mouse(22433) X-box binding protein 1
- Rat(289754) X-box binding protein 1
- Zebrafish(140614) X-box binding protein 1
- fruit fly(44226) X box binding protein-1
- chicken(416918) X-box binding protein 1
- dog(477532) X-box binding protein 1
- cow(541236) X-box binding protein 1
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-XBP1s Antibody, clone 143F (active form), clone 143F, from mouse,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-XBP1 antibody produced in rabbit, ,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
western blot
western blot
Anti-XBP1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
bovine, human
Applicazione
western blot
Anti-XBP-1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunocytochemistry
western blot
immunocytochemistry
western blot
Monoclonal Anti-XBP1 antibody produced in mouse, clone 3F5, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunofluorescence
western blot
immunofluorescence
western blot