UPF3B
UPF3 regulator of nonsense transcripts homolog B (yeast)
Sinonimi:
HUPF3B, MRXS14, RENT3B, UPF3X
Specie:
Human UPF3B (65109), Mouse Upf3b (68134), Rat Upf3b (313449), domestic cat UPF3B (101084940), cow UPF3B (616181), naked mole-rat Upf3b (101700790), Zebrafish upf3b (393929), dog UPF3B (481031), chicken UPF3B (100858231), sheep UPF3B (101101868)
ID UniProtKB:
ID gene:
- Human(65109) Summary: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(68134) UPF3 regulator of nonsense transcripts homolog B (yeast)
- Rat(313449) UPF3 regulator of nonsense transcripts homolog B (yeast)
- domestic cat(101084940) UPF3 regulator of nonsense transcripts homolog B (yeast)
- cow(616181) UPF3 regulator of nonsense transcripts homolog B (yeast)
- naked mole-rat(101700790) UPF3 regulator of nonsense transcripts homolog B (yeast)
- Zebrafish(393929) UPF3 regulator of nonsense transcripts homolog B (yeast)
- dog(481031) UPF3 regulator of nonsense transcripts homolog B (yeast)
- chicken(100858231) UPF3 regulator of nonsense transcripts homolog B (yeast)
- sheep(101101868) UPF3 regulator of nonsense transcripts homolog B (yeast)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-UPF3B antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
western blot
western blot
Anti-UPF3B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence
western blot
western blot
Anti-UPF3B antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot