PML
promyelocytic leukemia
Sinonimi:
MYL, PP8675, RNF71, TRIM19
Specie:
Human PML (5371), Mouse Pml (18854), Rat Pml (315713), chicken PML (415302), chicken PML (415304), domestic cat PML (101086975), dog PML (487641), sheep PML (101111580), cow PML (100138545), Horse PML (100062744) ...Più
ID UniProtKB:
ID gene:
- Human(5371) Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Mouse(18854) promyelocytic leukemia
- Rat(315713) promyelocytic leukemia
- chicken(415302) promyelocytic leukemia
- chicken(415304) promyelocytic leukemia
- domestic cat(101086975) promyelocytic leukemia
- dog(487641) promyelocytic leukemia
- sheep(101111580) promyelocytic leukemia
- cow(100138545) promyelocytic leukemia
- Horse(100062744) promyelocytic leukemia
- naked mole-rat(101707749) promyelocytic leukemia
- domestic guinea pig(100720832) promyelocytic leukemia
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anticorpo anti-PML, clone 36.1-104, clone 36.1-104, Upstate®, from mouse,
Reattività con
mouse
Applicazione
immunocytochemistry
western blot
western blot
Anti-PML antibody, Mouse monoclonal, clone PML-97, purified from hybridoma cell culture,
Reattività con
hamster, human, mouse
Applicazione
ELISA
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
Rabbit anti-PML Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.,
Reattività con
human
Applicazione
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-PML Isoform II Antibody, clone 1A8.1, clone 1A8.1, from mouse,
Reattività con
human
Applicazione
immunocytochemistry
western blot
western blot
Anti-PML antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry