NUDT1
nudix (nucleoside diphosphate linked moiety X)-type motif 1
Sinonimi:
MTH1
Specie:
Human NUDT1 (4521), Mouse Nudt1 (17766), Rat Nudt1 (117260), dog NUDT1 (489894), Zebrafish nudt1 (406727), chicken NUDT1 (416467), domestic guinea pig Nudt1 (100730917), naked mole-rat Nudt1 (101712324), domestic cat NUDT1 (101091068), cow NUDT1 (525496)
ID UniProtKB:
ID gene:
- Human(4521) Summary: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
- Mouse(17766) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- Rat(117260) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- dog(489894) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- Zebrafish(406727) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- chicken(416467) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- domestic guinea pig(100730917) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- naked mole-rat(101712324) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- domestic cat(101091068) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- cow(525496) nudix (nucleoside diphosphate linked moiety X)-type motif 1
- sheep(101119103) nudix (nucleoside diphosphate linked moiety X)-type motif 1
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-NUDT1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-MTH1 Antibody, clone 11A3.2, clone 11A3.2, from mouse,
Reattività con
human
Applicazione
western blot
Anti-NUDT1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
western blot
Anti-NUDT1 antibody produced in rabbit, ,
Reattività con
human
Applicazione
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot