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Merck

JAK1

Janus kinase 1

Sinonimi:
JAK1A, JAK1B, JTK3
Specie:
ID UniProtKB:
ID gene:
  • Human(3716) Summary: Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]
  • Mouse(16451) Janus kinase 1
  • Rat(84598) Janus kinase 1
  • naked mole-rat(101710283) Janus kinase 1
  • domestic guinea pig(100726895) Janus kinase 1
  • Domestic Rabbit(100352594) Janus kinase 1
  • sheep(101110716) Janus kinase 1
  • domestic cat(101084377) Janus kinase 1
  • Horse(100054008) Janus kinase 1
  • cow(537201) Janus kinase 1
  • dog(442952) Janus kinase 1
  • Zebrafish(30280) Janus kinase 1
  • chicken(395681) Janus kinase 1

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ELISA

N° Catalogo
Descrizione
Specie
Phosphotyrosine JAK1 / Tyrosine-protein Kinase JAK1 ELISA Kit, ,
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-JAK1 Antibody, serum, Upstate®,
Reattività con
hamster, human, mouse, rabbit, rat
Applicazione
immunoprecipitation (IP)
western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry

western blot
Anti-phospho-JAK1 (pTyr1022) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
western blot
Anti-JAK1 Antibody, clone 1I13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
bovine, canine, human, monkey, mouse, porcine, rat
Applicazione
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-JAK1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunohistochemistry

western blot

Proteins

N° Catalogo
Descrizione
Specie
JAK1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human JAK1, amino acids 866-end, expressed by baculovirus in Sf21 insect cells. Activated in vitro by auto-phosphorylation. For use in Kinase Assays.,
Specie
human
Jak1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting mouse Jak1,
Specie
mouse
MISSION® esiRNA, targeting human JAK1,
Specie
human