INPP5D
inositol polyphosphate-5-phosphatase, 145kDa
Sinonimi:
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN
Specie:
Human INPP5D (3635), Mouse Inpp5d (16331), Rat Inpp5d (54259), chicken INPP5D (424745), Zebrafish inpp5d (559103), naked mole-rat Inpp5d (101711777), domestic guinea pig Inpp5d (100722743), sheep INPP5D (101112941), Horse INPP5D (100064896), cow INPP5D (507329) ...Più
ID UniProtKB:
ID gene:
- Human(3635) Summary: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Mouse(16331) inositol polyphosphate-5-phosphatase D
- Rat(54259) inositol polyphosphate-5-phosphatase D
- chicken(424745) inositol polyphosphate-5-phosphatase, 145kDa
- Zebrafish(559103) inositol polyphosphate-5-phosphatase, 145kDa
- naked mole-rat(101711777) inositol polyphosphate-5-phosphatase, 145kDa
- domestic guinea pig(100722743) inositol polyphosphate-5-phosphatase, 145kDa
- sheep(101112941) inositol polyphosphate-5-phosphatase, 145kDa
- Horse(100064896) inositol polyphosphate-5-phosphatase, 145kDa
- cow(507329) inositol polyphosphate-5-phosphatase, 145kDa
- domestic cat(101100500) inositol polyphosphate-5-phosphatase, 145kDa
- dog(100688270) inositol polyphosphate-5-phosphatase, 145kDa
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-INPP5D antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-phospho-SHIP1 (pTyr1021) antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot
western blot
Anti-SHIP1 antibody produced in rabbit, ,
Reattività con
human, mouse, rat
Applicazione
immunohistochemistry
western blot
western blot
Anti-SHIP1 Antibody, from rabbit, purified by affinity chromatography,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-SHIP1 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
western blot
western blot
esiRNA
N° Catalogo
Descrizione
Specie