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Merck

GRN

granulin

Sinonimi:
CLN11, GEP, GP88, PCDGF, PEPI, PGRN
Specie:
ID UniProtKB:
ID gene:
  • Human(2896) Summary: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
  • Mouse(14824) granulin
  • Rat(29143) granulin
  • fruit fly(40962) grain
  • dog(480501) granulin
  • Horse(100051035) granulin
  • domestic cat(101100680) granulin
  • cow(767942) granulin
  • sheep(101115470) granulin
  • Domestic Rabbit(100349528) granulin
  • domestic guinea pig(100135533) granulin
  • naked mole-rat(101715753) granulin

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ELISA

N° Catalogo
Descrizione
Specie
Human PGRN ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Specie
human
Mouse Grn / Granulins ELISA Kit, ,
Specie
mouse

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-GRN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human, mouse, rat
Applicazione
immunofluorescence
immunohistochemistry
Anti-Granulin (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody,
Reattività con
human
Applicazione
immunofluorescence
western blot
Anti-GRN antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
western blot
Anti-Progranulin/GRN Antibody, clone 8H10, clone 8H10, from rat,
Reattività con
mouse
Applicazione
immunohistochemistry
western blot
Anti-GRN antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
immunohistochemistry

Proteins

N° Catalogo
Descrizione
Specie
Progranulin human, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE),
Specie
human
Progranulin mouse, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE),
Specie
mouse
Granulin C human, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE),
Specie
human
Progranulin mouse, recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE),
Specie
mouse
Progranulin rat, recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE),
Specie
rat

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human GRN,
Specie
human
MISSION® esiRNA, targeting mouse Grn,
Specie
mouse