DIO3
deiodinase, iodothyronine, type III
Sinonimi:
5DIII, D3, DIOIII, TXDI3
Specie:
Human DIO3 (1735), Mouse Dio3 (107585), Rat Dio3 (29475), naked mole-rat Dio3 (101697914), Domestic Rabbit DIO3 (100357267), Horse DIO3 (100146344), sheep DIO3 (100142657), dog DIO3 (612596), domestic cat DIO3 (101094186), chicken DIO3 (395939)
ID UniProtKB:
ID gene:
- Human(1735) Summary: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
- Mouse(107585) deiodinase, iodothyronine type III
- Rat(29475) deiodinase, iodothyronine, type III
- naked mole-rat(101697914) deiodinase, iodothyronine, type III
- Domestic Rabbit(100357267) deiodinase, iodothyronine, type III
- Horse(100146344) deiodinase, iodothyronine, type III
- sheep(100142657) deiodinase, iodothyronine, type III
- dog(612596) deiodinase, iodothyronine, type III
- domestic cat(101094186) deiodinase, iodothyronine, type III
- chicken(395939) deiodinase, iodothyronine, type III
- cow(494549) deiodinase, iodothyronine, type III
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Antibodies
Numero di prodotto
Descrizione
Reattività con
Applicazione
Anti-DIO3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
ANTI-DIO3 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot