CTSF
cathepsin F
Sinonimi:
CATSF, CLN13
Specie:
Human CTSF (8722), Mouse Ctsf (56464), Rat Ctsf (361704), domestic guinea pig Ctsf (100730626), naked mole-rat Ctsf (101719972), Horse CTSF (100058569), domestic cat CTSF (101099835), sheep CTSF (780471), Zebrafish ctsf (565588), dog CTSF (476010)
ID UniProtKB:
ID gene:
- Human(8722) Summary: Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008]
- Mouse(56464) cathepsin F
- Rat(361704) cathepsin F
- domestic guinea pig(100730626) cathepsin F
- naked mole-rat(101719972) cathepsin F
- Horse(100058569) cathepsin F
- domestic cat(101099835) cathepsin F
- sheep(780471) cathepsin F
- Zebrafish(565588) cathepsin F
- dog(476010) cathepsin F
- cow(509715) cathepsin F
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-CTSF antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
western blot
Proteins
N° Catalogo
Descrizione
Specie
Cathepsin F Active human, recombinant, expressed in FreeStyle™ 293-F cells, ≥90% (SDS-PAGE),
Specie
human