CIITA
class II, major histocompatibility complex, transactivator
Sinonimi:
C2TA, CIITAIV, MHC2TA, NLRA
Specie:
Human CIITA (4261), Mouse Ciita (12265), Rat Ciita (85483), Zebrafish ciita (100003537), chicken CIITA (427676), dog CIITA (490008), sheep CIITA (101106564), domestic guinea pig Ciita (100726338), Horse CIITA (100056546), Domestic Rabbit CIITA (100338894) ...Più
ID UniProtKB:
ID gene:
- Human(4261) Summary: This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008]
- Mouse(12265) class II transactivator
- Rat(85483) class II, major histocompatibility complex, transactivator
- Zebrafish(100003537) class II, major histocompatibility complex, transactivator
- chicken(427676) class II, major histocompatibility complex, transactivator
- dog(490008) class II, major histocompatibility complex, transactivator
- sheep(101106564) class II, major histocompatibility complex, transactivator
- domestic guinea pig(100726338) class II, major histocompatibility complex, transactivator
- Horse(100056546) class II, major histocompatibility complex, transactivator
- Domestic Rabbit(100338894) class II, major histocompatibility complex, transactivator
- naked mole-rat(101721690) class II, major histocompatibility complex, transactivator
- cow(508720) class II, major histocompatibility complex, transactivator
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-CIITA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunofluorescence
Anti-CIITA Antibody, from rabbit, purified by affinity chromatography,
Reattività con
human, mouse
Applicazione
immunohistochemistry
western blot
western blot
Anti-CIITA antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-CIITA antibody, Mouse monoclonal, clone 7-1H, purified from hybridoma cell culture,
Reattività con
human, mouse
Applicazione
immunocytochemistry
western blot
western blot