APPL2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Sinonimi:
DIP13B
Specie:
Human APPL2 (55198), Mouse Appl2 (216190), Rat Appl2 (362860), dog APPL2 (481297), domestic guinea pig Appl2 (100717140), Zebrafish appl2 (100000135), cow APPL2 (515605), domestic cat APPL2 (101089119), cow APPL2 (788375), naked mole-rat Appl2 (101696710) ...Più
ID UniProtKB:
ID gene:
- Human(55198) Summary: The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
- Mouse(216190) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- Rat(362860) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- dog(481297) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- domestic guinea pig(100717140) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- Zebrafish(100000135) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- cow(515605) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- domestic cat(101089119) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- cow(788375) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2-like
- naked mole-rat(101696710) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- sheep(101114693) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
- chicken(418075) adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
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Antibodies
N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-APPL2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
western blot
western blot
Anti-APPL2 antibody produced in mouse, IgG fraction of antiserum, buffered aqueous solution,
Reattività con
human
Applicazione
immunofluorescence
western blot
western blot
Anti-APPL2 (481-494) antibody produced in rabbit, IgG fraction of antiserum,
Reattività con
human
Applicazione
western blot
Monoclonal Anti-DIP13B antibody produced in mouse, clone 1C10, purified immunoglobulin, buffered aqueous solution,
Reattività con
human
Applicazione
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-APPL2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry