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Merck

Role of microenvironmental periostin in pancreatic cancer progression.

Oncotarget (2016-08-23)
Yang Liu, Fan Li, Feng Gao, Lingxi Xing, Peng Qin, Xingxin Liang, Jiajie Zhang, Xiaohui Qiao, Lizhou Lin, Qian Zhao, Lianfang Du
RÉSUMÉ

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a prominent desmoplastic reaction. Pancreatic stellate cells (PSCs) are the principal effector cells responsible for stroma production. Aberrant up-regulation of periostin expression has been reported in activated PSCs. In this study, we investigated the role of periostin and the mechanisms underlying its aberrant upregulation in PDAC. We used lentiviral shRNA and human recombinant periostin protein to down and up regulate periostin expression

MATÉRIAUX
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Description du produit

Sigma-Aldrich
Human Periostin ELISA Kit, for cell culture supernatants, plasma, and serum samples