Accéder au contenu
Merck

Involvement of PINK1/parkin-mediated mitophagy in ZnO nanoparticle-induced toxicity in BV-2 cells.

International journal of nanomedicine (2017-03-24)
Limin Wei, Jianfeng Wang, Aijie Chen, Jia Liu, Xiaoli Feng, Longquan Shao
RÉSUMÉ

With the increasing application of zinc oxide nanoparticles (ZnO NPs) in biological materials, the neurotoxicity caused by these particles has raised serious concerns. However, the underlying molecular mechanisms of the toxic effect of ZnO NPs on brain cells remain unclear. Mitochondrial damage has been reported to be a factor in the toxicity of ZnO NPs. PINK1/parkin-mediated mitophagy is a newly emerging additional function of autophagy that selectively degrades impaired mitochondria. Here, a

MATÉRIAUX
Référence du produit
Marque
Description du produit

Sigma-Aldrich
JC-1, solid
Sigma-Aldrich
Pentostatin, ≥95% (HPLC)
Sigma-Aldrich
MISSION® esiRNA, targeting human PINK1, PINK1-AS