- Enantioselective total synthesis of (-)-dactylolide.
Enantioselective total synthesis of (-)-dactylolide.
Organic letters (2006-03-10)
Ignace Louis, Natasha L Hungerford, Edward J Humphries, Malcolm D McLeod
PMID16524282
RÉSUMÉ
[reaction: see text] The enantioselective total synthesis of (-)-dactylolide is reported. The absolute stereochemistry of the tetrahydropyran was established by catalytic asymmetric Jacobsen hetero-Diels-Alder reaction. The remote C19 stereocenter was introduced by a sequence of chelation-controlled Grignard addition and Ireland-Claisen rearrangement.
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