Improved synthetic route to methyl 1-fluoroindan-1-carboxylate (FICA Me ester) and 4-methyl derivatives.

Improved synthetic route to methyl 1-fluoroindan-1-carboxylate (FICA Me ester) and 4-methyl derivatives.

Chemical & pharmaceutical bulletin (2014-06-13)

Jyunichi Koyanagi, Tomoyo Kamei, Miyuki Ishizaki, Hiroshi Nakamura, Tamiko Takahashi

PMID24920050

RÉSUMÉ

An improved synthetic route has been developed for the preparation of methyl 1-fluoroindan-1-carboxylate (FICA Me ester) from 1-indanone. Methyl 4-methyl-1-fluoroindan-1-carboxylate (4-Me-FICA Me ester) was also prepared following the same procedure.