Development of a second generation palladium-catalyzed cycloalkenylation and its application to bioactive natural product synthesis.

Development of a second generation palladium-catalyzed cycloalkenylation and its application to bioactive natural product synthesis.

Natural product communications (2013-08-29)

Masahiro Toyota

RÉSUMÉ

A novel palladium-catalyzed intramolecular oxidative alkylation of unactivated olefins is described. This protocol was devised to solve one of the drawbacks of the original palladium-catalyzed cycloalkenylation that we developed. We call this new procedure the 'second generation palladium-catalyzed cycloalkenylation'. This protocol has been applied to the total syntheses of cis-195A, trans-195A, boonein, scholareins A, C, D, and alpha-skytanthine.

MATÉRIAUX

Référence du produit

Marque

Description du produit

203939

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326666

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686468

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203998

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267082

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267112

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287474

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373206

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Palladium, tube, 200mm, outside diameter 2.0mm, inside diameter 1.6mm, wall thickness 0.2mm, as drawn, 99.95%

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Palladium, foil, 25x25mm, thickness 0.50mm, as rolled, 99.99+%

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Palladium, rod, 10mm, diameter 6.0mm, 99.95%

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Palladium, wire reel, 1m, diameter 0.05mm, as drawn, 99.9%

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