- Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.
Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.
Bioorganic & medicinal chemistry letters (2001-10-26)
K G Liu, M H Lambert, L M Leesnitzer, W Oliver, R J Ott, K D Plunket, L W Stuart, P J Brown, T M Willson, D D Sternbach
PMID11677135
RÉSUMÉ
We have developed a general solid-phase synthesis for identification of PPAR ligands. Synthesis of a 480-member library led to the identification of a potent PPAR gamma/delta dual agonist 23. Compound 23 showed good plasma exposure in rats and demonstrated antihyperglycemic and antihyperlipidemic efficacy in diabetic fatty Zucker rats.
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