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Solvent dependent reductive defluorination of aliphatic C-F bonds employing Sm(HMDS)2.

Solvent dependent reductive defluorination of aliphatic C-F bonds employing Sm(HMDS)2.

Chemical communications (Cambridge, England) (2013-01-30)

Mario Janjetovic, Annika M Träff, Tobias Ankner, Jenny Wettergren, Göran Hilmersson

RÉSUMÉ

Sm(HMDS)(2) in n-hexane mediates fast cleavage of primary, secondary and tertiary alkyl fluorides in good to excellent yields. In n-hexane Sm(HMDS)(2) exhibits uniquely enhanced reductive ability towards the C-F bond compared to when using THF as solvent.

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