Structure and synthesis of an immunoactive lipopeptide, WS1279, of microbial origin.

Structure and synthesis of an immunoactive lipopeptide, WS1279, of microbial origin.

Chemical & pharmaceutical bulletin (1991-03-01)

Y Tsuda, Y Okada, M Tanaka, N Shigematsu, Y Hori, T Goto, M Hashimoto

PMID2070441

RÉSUMÉ

The structure of WS1279, isolated from Streptomyces sp. as an immunoactive lipopeptide, has been deduced on the basis of chemical and physical evidence as S-[2,3-bis(palmitoyloxy)propyl]-N alpha-palmitoyl-Cys-Asn-Ser-Gly-Gly-Ser- OH. This was confirmed by synthesis.