- Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert-butyl thiol linker.
Fmoc-based synthesis of peptide thioesters for native chemical ligation employing a tert-butyl thiol linker.
Organic letters (2011-03-02)
Richard Raz, Jörg Rademann
PMID21355617
RÉSUMÉ
tert-Butyl thioesters display an astonishing stability toward secondary amines in basic milieu, in contrast to other alkyl and aryl thioesters. Exploiting this enhanced stability, peptide thioesters were synthesized in a direct manner, applying a tert-butyl thiol linker for Fmoc-based solid-phase peptide synthesis.
MATÉRIAUX