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Bridgehead enolates and bridgehead alkenes in a welwistatin model series.

Chemical communications (Cambridge, England) (2009-03-05)
Valerie Boissel, Nigel S Simpkins, Gurdip Bhalay, Alexander J Blake, William Lewis
RÉSUMÉ

Bridgehead metallation is possible in a ketone having the welwistatin skeleton, and this facilitates installation of the isothiocyanate function present in the natural product, and also enables synthesis of remarkable bridgehead alkenes.

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Sigma-Aldrich
Selenium dioxide, reagent grade, powder, 98%
Sigma-Aldrich
Selenium dioxide, ≥99.9% trace metals basis
Sigma-Aldrich
Selenium dioxide, 99.999% trace metals basis
Sigma-Aldrich
Selenium dioxide, ReagentPlus®, powder, 99.8% trace metals basis