Accéder au contenu
Merck

The chemoselective and efficient deprotection of silyl ethers using trimethylsilyl bromide.

Organic & biomolecular chemistry (2008-06-06)
Syed Tasadaque A Shah, Patrick J Guiry
RÉSUMÉ

An efficient and chemoselective cleavage of silyl ethers (primary, secondary and aromatic) by using catalytic quantities of trimethylsilyl bromide (TMSBr) in methanol is reported. A wide range of alkyl silyl ethers such as TBS, TIPS, and TBDPS can be chemoselectively cleaved in high yield in the presence of aryl silyl ethers. The deprotection of silyl esters was also achieved employing catalytic quantities of TMSBr.

MATÉRIAUX
Référence du produit
Marque
Description du produit

Sigma-Aldrich
Bromotrimethylsilane, 97%
Sigma-Aldrich
Bromotrimethylsilane, purum, ≥97.0% (AT)