Michael addition of pyrimidine with disaccharide acrylates catalyzed in organic medium with lipase M from Mucor javanicus.

The Michael addition of fluorouracil (0.01 mol), uracil (0.01 mol), thymine (0.01 mol) to disaccharide acrylates (0.03 mol) was carried out in pyridine (20 ml) at 50 degrees C for 72 h with lipase M from Mucor javanicus (200 mg). Six new pyrimidine derivatives containing a branched sugar were obtained in yields from 56 to 75%.