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SAB2501042

Sigma-Aldrich

Anti-TIP30/CC3 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-HIV-1 Tat interactive protein 2, Anti-HTATIP2, Anti-Tat-interacting protein (30 kDa)

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

goat

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

human

Technique(s)

indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Q9BUP3

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... HTATIP2(10553)

Catégories apparentées

Description générale

Tat-interacting protein 30 (TIP30), also called CC3/ HIV-1 tat interactive protein 2 (HTATIP2), is a putative tumor suppressor. It is encoded by the gene mapped to human chromosome 11p15.1. TIP30 is primarily localized in cytoplasm and it belongs to short-chain dehydrogenases/reductase (SDR) family. The encoded protein is extensively expressed in various human tissues, such as the heart, brain, lung, kidney and pancreas.

Immunogène

Peptide with sequence AETEALSKLREDFR-C from the N Terminus of the protein sequence according to NP_006401.

Actions biochimiques/physiologiques

Tat-interacting protein 30 (TIP30) has an ability to promote apoptosis and suppress metastasis and angiogenesis. It is also implicated in regulation of DNA repair and tumor cell metabolism. Down-regulated expression of the gene is associated with the development of various cancers, including melanoma, breast cancer, neuroblastoma, glioblastoma, colon cancer, lung cancer and hepatocellular carcinoma. Elevated expression of the gene in glioma cells inhibits tumor proliferation, metastasis and migration. Thus, TIP30 can be considered as a potent target for treating glioma patients.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319

Conseils de prudence

P305 + P351 + P338

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

TIP30 Deficiency Increases Susceptibility to Tumorigenesis
Ito M, et al.
Cancer Research, 63(24), 8763-8767 (2003)
TIP30: a novel tumor-suppressor gene.
Yu X, et al.
Oncology Research, 22(5-6), 339-348 (2015)
Overexpression of TIP30 inhibits the growth and invasion of glioma cells
Hu Y, et al.
Molecular Medicine Reports, 13(1), 605-612 (2016)
Tat-Interacting Protein 30 (TIP30) Expression Serves as a New Biomarker for Tumor Prognosis: A Systematic Review and Meta-Analysis
Xu T, et al.
PLoS ONE, 11(12), e0168408-e0168408 (2016)
Xin Tong et al.
The American journal of pathology, 174(5), 1931-1939 (2009-04-08)
The HIV Tat-interacting protein (TIP30), also called CC3 or HTIP2, is encoded by Tip30, a putative tumor-suppressor gene located on human chromosome 11p15.1. In this study, we investigated the role of TIP30 in the progression and metastasis of lung cancer.

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