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N3905

Sigma-Aldrich

Nicarbazin

Synonyme(s) :

N,N′-bis(4-Nitrophenyl)urea compound with 4,6-dimethyl-2-pyrimidinone

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About This Item

Formule empirique (notation de Hill):
C13H10N4O5 · C6H8N2O
Numéro CAS:
330-95-0
Poids moléculaire :
426.38
Numéro CE :
206-359-1
Numéro MDL:
MFCD00867204
Code UNSPSC :
51102829
ID de substance PubChem :
329818641
Nomenclature NACRES :
NA.85

Forme

powder

Spectre d'activité de l'antibiotique

parasites

Mode d’action

cell membrane | interferes

Chaîne SMILES 

Cc1cc(C)nc(O)n1.[O-][N+](=O)c2ccc(NC(=O)Nc3ccc(cc3)[N+]([O-])=O)cc2

InChI

1S/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9)

Clé InChI

UKHWDRMMMYWSFL-UHFFFAOYSA-N

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Application

Nicarbazin is a coccidiostat (antiprotozoal agent) in the poultry industry and is a contraceptive for resident Canada geese and waterfowl. It is used to study avian reproduction and is used to interfere with the formation of the vitelline (yolk) membrane in bird eggs. It has been used to study how delivery method can effect plasma levels of 4,4′-dinitrocarbanilide (DNC), which is the active anticoccidial component of Nicarbazin.

Actions biochimiques/physiologiques

Nicarbazin affects avian reproduction by reducing egg production, egg weight, and egg hatchability. The mechanism of action of Nicarbazin is unknown.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

G F Mathis et al.
Veterinary parasitology, 121(1-2), 1-9 (2004-04-28)
A 56-day floor pen study was conducted to determine the appropriate time to administer toltrazuril (Baycox) (TOL) for control of coccidiosis in broiler chickens. Litter was seeded with field strains of Eimeria acervulina, Eimeria maxima and Eimeria tenella. On Days
Martin Danaher et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(1), 32-40 (2007-10-25)
A survey was carried out on the occurrence of dinitrocarbanilide (DNC), the marker residue for nicarbazin, in poultry produced in Ireland during 2002-2004. Liver (n = 736) and breast muscle samples (n = 342) were tested. DNC residues were found
V Gaudin et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(23), 2358-2362 (2009-04-07)
Nicarbazin, a coccidiostat, is used as a feed additive in poultry but not in laying hens. Feed contamination may however occur resulting in residues being present in eggs. As a Maximum Residue Limit (MRL) does not exist for nicarbazin residues
J A Tarbin et al.
Food additives and contaminants, 22(11), 1126-1131 (2005-12-08)
The change of concentration of residues of the marker compound for the anti-coccidial drug nicarbazin, N,N'-bis(4-nitrophenyl)urea (dinitrocarbanilide, DNC), was investigated in model oil and aqueous solutions and in chicken muscle and egg. In model aqueous solutions, DNC decreased rapidly in
M O'Keeffe et al.
Food additives and contaminants, 24(9), 923-934 (2007-08-11)
Investigations were undertaken to identify causes for the occurrence of high levels of the zootechnical feed additive nicarbazin in broiler liver at slaughter. The first investigation on 32 commercial broiler flocks involved sampling and analysis for nicarbazin (as dinitrocarbanilide, DNC)
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