GS05
GST S1-1, Recombinant Human
Synonyme(s) :
GSTS, GSTS1, PGD2, PGDS, hematopoietic prostaglandin D synthase
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About This Item
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.26
Produits recommandés
Source biologique
human
Niveau de qualité
Produit recombinant
expressed in E. coli
Pureté
>95% (SDS-PAGE)
Forme
frozen liquid
Activité spécifique
24.07
Poids mol.
23 kDa
Concentration
0.9 mg/mL
Température de stockage
−70°C
Informations sur le gène
human ... HPGDS(27306)
Description générale
using spectrophotometric determination of 1-fluoro-2,4-dinitrobenzene (FDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.
Actions biochimiques/physiologiques
Glutathione S-transferase sigma 1, also know as hematopoietic prostaglandin D synthase (HPGDS) is an enzyme that in humans is encoded by the HPGDS gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.
Stockage et stabilité
The enzyme should be used by the end-user customer within 1 year of receipt.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Morten Hohwy et al.
Journal of medicinal chemistry, 51(7), 2178-2186 (2008-03-18)
We describe the discovery of novel inhibitors of prostaglandin D2 synthase (PGDS) through fragment-based lead generation and structure-based drug design. A library of 2500 low-molecular-weight compounds was screened using 2D nuclear magnetic resonance (NMR), leading to the identification of 24
Marcus Kjellander et al.
Analytical biochemistry, 446, 59-63 (2013-10-26)
The previously uncharacterized Drosophila melanogaster Epsilon-class glutathione transferases E6 and E7 were immobilized on nanoporous alumina. The nanoporous anodized alumina membranes were derivatized with 3-aminopropyl-triethoxysilane, and the amino groups were activated with carbonyldiimidazole to allow coupling of the enzymes via
Brigette L Tippin et al.
Prostaglandins & other lipid mediators, 97(1-2), 22-28 (2011-08-09)
Intestinal tumors in Apc(Min/+) mice are suppressed by over-production of HPGDS, which is a glutathione transferase that forms prostaglandin D(2) (PGD(2)). We characterized naturally occurring HPGDS isoenzymes, to see if HPGDS variation is associated with human colorectal cancer risk. We
Tsuyoshi Inoue et al.
Journal of biochemistry, 135(3), 279-283 (2004-04-29)
Hematopoietic prostaglandin (PG) D synthase (H-PGDS) is responsible for the production of PGD(2) as an allergy or inflammation mediator in mast and Th2 cells. We determined the X-ray structure of human H-PGDS complexed with an inhibitor, 2-(2'-benzothiazolyl)-5-styryl-3-(4'-phthalhydrazidyl) tetrazolium chloride (BSPT)
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