B3811

B-9430 trifluoroacetate salt

≥98% (HPLC)

• Synonyme(s) : D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp³, Igl⁵, D-Igl⁷, Oic⁸]-Bradykinin trifluoroacetate salt
• Formule empirique (notation de Hill): C₆₄H₉₅N₁₉O₁₃ · xC₂HF₃O₂
• Numéro CAS: 180981-09-3
• Poids moléculaire : 1338.56 (free base basis)
• Code UNSPSC : 12352200

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: solid
• Conditions de stockage: protect from light; under inert gas
• Solubilité: H₂O: ≥2 mg/mL
• Conditions d'expédition: wet ice
• Température de stockage: −20°C

Description

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg

Actions biochimiques/physiologiques

B-9430 was developed by Gera at the Stewart laboratory¹ and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA₂ = 8.6) and B1 receptors (pA₂ = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.

Attention

Product is air and light sensitive. Store in the dark.

Informations sur la sécurité

• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable