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FCMAB195F

Sigma-Aldrich

Milli-Mark® Anti-CD41-FITC Antibody, clone 5B12

clone 5B12, Milli-Mark®, from mouse

Synonyme(s) :

Integrin alpha-IIb, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.44

Source biologique

mouse

Niveau de qualité

100

Conjugué

FITC conjugate

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

5B12, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Milli-Mark®

Technique(s)

flow cytometry: suitable

Isotype

IgG1κ

Numéro d'accès NCBI

NP_000410

Numéro d'accès UniProt

P08514

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ITGA2B(3674)

Catégories apparentées

Description générale

CD41 is the α-subunit of the CD41/CD61 complex (GPIIb-IIIa), a calcium-dependent, non-covalently associated heterodimer. CD41 is a 135 kDa molecule, consisting of 2 peptides: a 120 kDa α chain and a 23 kDa β chain. The α chain and the β chain are linked by a single disulphide bond. The α chain contains four calcium-binding sites and is entirely extracellular, while the β-chain has extracellular, transmembrane, and cytoplasmic domains (Sun, 1997). The CD41/CD61 complex appears early in megakaryocyte maturation (Vinci, 1984). Anti-CD41, 5B12, was included in the Fifth International Workshop and Conference on Human Leukocyte Differentiation Antigens and studies by a number of laboratories confirmed its reactivity with CD41 (Honda, 1995).

Spécificité

Antibody recognizes Human CD41 antigen.

Immunogène

Normal human platelets

Application

Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
This Milli-Mark Anti-CD41-FITC Antibody, clone 5B12 is validated for use in FC for the detection of CD41.

Qualité

Evaluated by flow cytometry using TF-1 cells

Description de la cible

135 kDa (Sun, 1997)

Forme physique

Protein A purified
Purified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.

Stockage et stabilité

Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

Remarque sur l'analyse

Control
TF-1 cells

Informations légales

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Francesca Patella et al.
Research and practice in thrombosis and haemostasis, 5(8), e12626-e12626 (2021-12-23)
Thrombotic thrombocytopenic purpura (TTP), caused by a genetic or autoimmune-driven lack of ADAMTS-13 activity, leads to high levels of the ultra-large von Willebrand factor (VWF) multimers produced by endothelial cells, causing excess platelet recruitment into forming thrombi, often with mortal
Francesca Patella et al.
Journal of cell science, 133(14) (2020-06-25)
The haemostatic protein von Willebrand factor (VWF) exists in plasma and subendothelial pools. The plasma pools are secreted from endothelial storage granules, Weibel-Palade bodies (WPBs), by basal secretion with a contribution from agonist-stimulated secretion, and the subendothelial pool is secreted

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