537011
Prolyl Endopeptidase Inhibitor II
The Prolyl Endopeptidase Inhibitor II, also referenced under CAS 108708-25-4, controls the biological activity of Prolyl Endopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonyme(s) :
Prolyl Endopeptidase Inhibitor II, Z-PP-CHO
Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
About This Item
Formule empirique (notation de Hill):
C18H22N2O4
Numéro CAS:
Poids moléculaire :
330.38
Code UNSPSC :
12352200
Produits recommandés
Niveau de qualité
Pureté
≥97% (HPLC)
Forme
oil
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
protect from light
Couleur
colorless to off-white
Solubilité
DMSO: 10 mg/mL
DMF: soluble
ethyl acetate: soluble
Conditions d'expédition
ambient
Température de stockage
−20°C
Description générale
A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively). Reported to form a hemiacetal with the active-site serine.
A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow, and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain, respectively). Reported to form a hemiacetal with the active site serine of the enzyme.
Actions biochimiques/physiologiques
Cell permeable: yes
Primary Target
Mouse brain prolylendooeotidase
Mouse brain prolylendooeotidase
Product does not compete with ATP.
Reversible: no
Target Ki: 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Standard Handling (A)
Séquence
Z-Pro-Pro-CHO
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Autres remarques
Fülöp, V., et al. 1998. Cell94, 161.
Kahyaoglu, A., et al. 1997. Biochem. J.322, 839.
Bakker, A.V., et al. 1990. Biochem. J.271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem.41, 69.
Kahyaoglu, A., et al. 1997. Biochem. J.322, 839.
Bakker, A.V., et al. 1990. Biochem. J.271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem.41, 69.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
Déjà en possession de ce produit ?
Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Zehavit Goldberg et al.
International journal of molecular sciences, 23(2) (2022-01-22)
The aim of this study was to characterize the distribution of the thrombin receptor, protease activated receptor 1 (PAR1), in the neuroretina. Neuroretina samples of wild-type C57BL/6J and PAR1-/- mice were processed for indirect immunofluorescence and Western blot analysis. Reverse
Chenxi Zhao et al.
Journal of neuroinflammation, 19(1), 189-189 (2022-07-17)
Nafamostat mesylate (nafamostat, NM) is an FDA-approved serine protease inhibitor that exerts anti-neuroinflammation and neuroprotective effects following rat spinal cord injury (SCI). However, clinical translation of nafamostat has been limited by an unclear administration time window and mechanism of action. Time
Valery Golderman et al.
Biomedicines, 10(6) (2022-06-25)
Thrombin is present in peripheral nerves and is involved in the pathogenesis of neuropathy. We evaluated thrombin activity in skin punch biopsies taken from the paws of male mice and rats and from the legs of patients with suspected small-fiber
Chenxi Zhao et al.
Neural regeneration research, 19(2), 434-439 (2023-07-25)
Argatroban is a synthetic thrombin inhibitor approved by U.S. Food and Drug Administration for the treatment of thrombosis. However, whether it plays a role in the repair of spinal cord injury is unknown. In this study, we established a rat
Mouhannad Malek et al.
Nature communications, 12(1), 2673-2673 (2021-05-13)
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. Here we reveal a
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
Contacter notre Service technique