TOP1
topoisomerase (DNA) I
Synonymes:
TOPI
Espèce(s):
Human TOP1 (7150), Mouse Top1 (21969), Rat Top1 (64550), domestic cat TOP1 (101093174), naked mole-rat Top1 (101704241), domestic guinea pig Top1 (100716716), sheep TOP1 (101103086), cow TOP1 (534799), dog TOP1 (477229), chicken TOP1 (396004) ...Plus
ID UniProtKB:
ID du gène:
- Human(7150) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
- Mouse(21969) topoisomerase (DNA) I
- Rat(64550) topoisomerase (DNA) I
- domestic cat(101093174) topoisomerase (DNA) I
- naked mole-rat(101704241) topoisomerase (DNA) I
- domestic guinea pig(100716716) topoisomerase (DNA) I
- sheep(101103086) topoisomerase (DNA) I
- cow(534799) topoisomerase (DNA) I
- dog(477229) topoisomerase (DNA) I
- chicken(396004) topoisomerase (DNA) I
- fruit fly(32458) Topoisomerase 1
- Zebrafish(327179) topoisomerase (DNA) I
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-Topoisomerase I-DNA Covalent Complexes Antibody, clone 1.1A, clone 1.1A, from mouse,
Espèces réactives
human, mouse
Application
ELISA
dot blot
flow cytometry
immunocytochemistry
dot blot
flow cytometry
immunocytochemistry
Monoclonal Anti-Topoisomerase I antibody produced in mouse, clone Mab1, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
microarray
western blot
western blot
Anti-TOP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-TOP1 antibody produced in mouse, clone 1A1, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Proteins
Référence du produit
Description
Espèce(s)
Topo I (197-651) (core domain) human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Espèce(s)
human
Topo I (N1-197) (NTD) human, recombinant, expressed in insect cells, ≥85% (SDS-PAGE),
Espèce(s)
human
Topo I (C651-765) (C terminal domain) human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Espèce(s)
human
Topo I (Y723F) (mt Y723F) human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Espèce(s)
human