TNNI1
troponin I type 1 (skeletal, slow)
Synonymes:
SSTNI, TNN1
Espèce(s):
Human TNNI1 (7135), Mouse Tnni1 (21952), Rat Tnni1 (29388), chicken TNNI1 (421161), cow TNNI1 (100301375), dog TNNI1 (100685160), Goat TNNI1 (100860774), domestic guinea pig Tnni1 (100733717), domestic cat TNNI1 (101096197), naked mole-rat Tnni1 (101720739)
ID UniProtKB:
ID du gène:
- Human(7135) Summary: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
- Mouse(21952) troponin I, skeletal, slow 1
- Rat(29388) troponin I type 1 (skeletal, slow)
- chicken(421161) troponin I type 1 (skeletal, slow)
- cow(100301375) troponin I type 1 (skeletal, slow)
- dog(100685160) troponin I type 1 (skeletal, slow)
- Goat(100860774) troponin I type 1 (skeletal, slow)
- domestic guinea pig(100733717) troponin I type 1 (skeletal, slow)
- domestic cat(101096197) troponin I type 1 (skeletal, slow)
- naked mole-rat(101720739) troponin I type 1 (skeletal, slow)
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-Cardiac Troponin I Antibody, clone 1F23, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-TNNI1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-TNNI1 (AB2) antibody produced in rabbit, IgG fraction of antiserum,
Espèces réactives
bovine, dog, goat, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-TNNI1 (AB1) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Proteins
Référence du produit
Description
Espèce(s)
Troponin1, His tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human