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Merck

PRKCE

protein kinase C, epsilon

Synonymes:
PKCE, nPKC-epsilon
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(5581) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
  • Mouse(18754) protein kinase C, epsilon
  • Rat(29340) protein kinase C, epsilon
  • chicken(421409) protein kinase C, epsilon
  • domestic cat(101100958) protein kinase C, epsilon
  • dog(609934) protein kinase C, epsilon
  • cow(507041) protein kinase C, epsilon
  • Horse(100053394) protein kinase C, epsilon
  • Domestic Rabbit(100009103) protein kinase C, epsilon
  • sheep(101110314) protein kinase C, epsilon
  • naked mole-rat(101700837) protein kinase C, epsilon
  • domestic guinea pig(100721814) protein kinase C, epsilon

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
Acide oléique, ≥99% (GC),
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-PKCε Antibody, Upstate®, from rabbit,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-PRKCE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
Anti-phospho-PKCepsilon Antibody (Ser729), from rabbit, purified by affinity chromatography,
Espèces réactives
human, mouse, rat
Application
western blot
Anti-PRKCE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-PRKCE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
H-7 dihydrochloride, ≥98% (HPLC),
Espèce(s)
human
Tamoxifen citrate salt, ≥99%,
Espèce(s)
human
Acide oléique, ≥99% (GC),
Espèce(s)
human
UCN-01, ≥97% (HPLC), powder,
Espèce(s)
human
GSK690693, ≥98% (HPLC),
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
PKCε Protein, active, 10 µg, Active, N-terminal His6-tagged, recombinant PKCε, amino acids 2-end. For use in Kinase Assays.,
Espèce(s)
human
PKC ε , active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Prkce,
Espèce(s)
mouse
MISSION® esiRNA, targeting human PRKCE,
Espèce(s)
human