PRKAR2A
protein kinase, cAMP-dependent, regulatory, type II, alpha
Synonymes:
PKR2, PRKAR2
Espèce(s):
Human PRKAR2A (5576), Mouse Prkar2a (19087), Rat Prkar2a (29699), sheep PRKAR2A (101118483), naked mole-rat Prkar2a (101706516), cow PRKAR2A (518399), dog PRKAR2A (100685147), cow PRKAR2A (100139910), domestic guinea pig Prkar2a (100728915)
ID UniProtKB:
ID du gène:
- Human(5576) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]
- Mouse(19087) protein kinase, cAMP dependent regulatory, type II alpha
- Rat(29699) protein kinase, cAMP dependent regulatory, type II alpha
- sheep(101118483) protein kinase, cAMP-dependent, regulatory, type II, alpha
- naked mole-rat(101706516) protein kinase, cAMP-dependent, regulatory, type II, alpha
- cow(518399) protein kinase, cAMP-dependent, regulatory, type II, alpha
- dog(100685147) protein kinase, cAMP-dependent, regulatory, type II, alpha
- cow(100139910) protein kinase, cAMP-dependent, regulatory, type II, alpha
- domestic guinea pig(100728915) protein kinase, cAMP-dependent, regulatory, type II, alpha
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-phospho PKA-RII (Ser96) Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
human, mouse, rat
Application
western blot
Anti-PRKAR2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Phospho-PKA RIIα (PRKAR2A)-S99 antibody produced in rabbit, ,
Espèces réactives
human
Application
western blot
Monoclonal Anti-PRKAR2A, (N-terminal) antibody produced in mouse, clone 3C7, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
western blot
Anti-PRKAR2A antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
western blot
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt, ≥97.0% (HPLC), powder,
Espèce(s)
human