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Merck

HMGCL

3-hydroxymethyl-3-methylglutaryl-CoA lyase

Synonymes:
HL
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(3155) Summary: The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • Mouse(15356) 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
  • Rat(79238) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • Zebrafish(394190) 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
  • naked mole-rat(101716848) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • domestic guinea pig(100713291) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • domestic cat(101099569) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • cow(317658) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • chicken(396316) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • dog(478187) 3-hydroxymethyl-3-methylglutaryl-CoA lyase
  • sheep(101119699) 3-hydroxymethyl-3-methylglutaryl-CoA lyase

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-HMGCL antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
western blot
Anti-HMGCL antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
Mevastatin, ≥98% (HPLC), powder or crystals,
Espèce(s)
rat, human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Hmgcl,
Espèce(s)
mouse