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Merck

CHRM4

cholinergic receptor, muscarinic 4

Synonymes:
HM4, M4R
Espèce(s):
Human CHRM4 (1132), Mouse Chrm4 (12672), Rat Chrm4 (25111), domestic guinea pig Chrm4 (100714736), naked mole-rat Chrm4 (101726411), Domestic Rabbit CHRM4 (100008791), dog CHRM4 (611314), cow CHRM4 (512928), sheep CHRM4 (101114554), domestic cat CHRM4 (101088360)
ID UniProtKB:
P08173, B2RPP4, Q0VD60, Q4VBK7
ID du gène:
  • Human(1132) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
  • Mouse(12672) cholinergic receptor, muscarinic 4
  • Rat(25111) cholinergic receptor, muscarinic 4
  • domestic guinea pig(100714736) cholinergic receptor, muscarinic 4
  • naked mole-rat(101726411) cholinergic receptor, muscarinic 4
  • Domestic Rabbit(100008791) cholinergic receptor, muscarinic 4
  • dog(611314) cholinergic receptor, muscarinic 4
  • cow(512928) cholinergic receptor, muscarinic 4
  • sheep(101114554) cholinergic receptor, muscarinic 4
  • domestic cat(101088360) cholinergic receptor, muscarinic 4
  • chicken(423195) cholinergic receptor, muscarinic 4

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
P6503
Pilocarpine hydrochloride, ≥99% (titration), powder,
Espèce(s)
human
A2251
Acetyl-β-methylcholine chloride, ≥98% (TLC), powder,
Espèce(s)
human
P6628
Pilocarpine nitrate salt, ≥98% (HPLC),
Espèce(s)
human
O100
Oxotremorine M, solid,
Espèce(s)
human
M104
(±)-Muscarine chloride hydrate, ≥98% (HPLC),
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
B1390
Bisacodyl, analytical standard, for drug analysis,
Espèce(s)
human
T9778
Tropicamide, solid,
Espèce(s)
human
S1875
(−)-Scopolamine hydrobromide trihydrate, ≥98% (HPLC), powder,
Espèce(s)
human
A0257
Atropine sulfate salt monohydrate, ≥97% (TLC), crystalline,
Espèce(s)
human
S8502
(−)-Scopolamine methyl bromide, ≥98% (HPLC), powder,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
MAB1578
Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 18C7.2, clone 18C7.2, Chemicon®, from mouse,
Espèces réactives
monkey
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
ZMS1165
Anti-CHRM4 Antibody, clone 18C7.2 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human
Application
ELISA
affinity binding assay
immunocytochemistry
western blot
SAB4300824
Anti-CHRM4 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
western blot
MAB1576
Anticorps anti-récepteur muscarinique acétylcholine m4, clone 17F10.2, purified antibody, clone 17F10.2, Chemicon®,
Espèces réactives
monkey, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
A8404
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Espèce(s)
human
D4526
Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Espèce(s)
human
51330
Harmaline, ≥95%,
Espèce(s)
human, rat

Small Molecule - Ligand

Référence du produit
Description
Espèce(s)
A138
Aminobenztropine, solid,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EMU046221
MISSION® esiRNA, targeting mouse Chrm4,
Espèce(s)
mouse