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Merck

ADRA2C

adrenoceptor alpha 2C

Synonymes:
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(152) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • Mouse(11553) adrenergic receptor, alpha 2c
  • Rat(24175) adrenoceptor alpha 2C
  • domestic guinea pig(100135477) adrenergic receptor, alpha 2c
  • domestic guinea pig(101787589) adrenoceptor alpha 2C
  • cow(101902575) adrenoceptor alpha 2C
  • cow(407139) alpha-2C adrenergic receptor
  • sheep(100170319) adrenoceptor alpha 2C
  • Zebrafish(266752) adrenergic, alpha-2C-, receptor
  • chicken(428799) adrenergic, alpha-2C-, receptor
  • dog(488793) adrenoceptor alpha 2C
  • domestic cat(101087990) adrenoceptor alpha 2C
  • domestic cat(100529244) adrenoceptor alpha 2C

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numéro du produit
Description
Espèce(s)
Xylazine hydrochloride, ≥99.0% (HPLC),
Espèce(s)
human
(−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate, 99%,
Espèce(s)
human
Guanabenz acetate salt, powder,
Espèce(s)
human
Guanfacine hydrochloride, ≥98% (HPLC),
Espèce(s)
human
Methyldopa, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Numéro du produit
Description
Espèce(s)
Yohimbine hydrochloride, ≥98% (HPLC), powder,
Espèce(s)
human
Idazoxan hydrochloride, ,
Espèce(s)
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
Espèce(s)
human
UK 14,304, ,
Espèce(s)
human
Mirtazapine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-Adrenergic Receptor α-2C antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
Anti-ADRA2C antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Monoclonal Anti-Alpha-2C antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Apc antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot
Monoclonal Anti-Alpha 2C Adrenergic Receptor - Biotin antibody produced in mouse, clone S330A-80, purified immunoglobulin,
Espèces réactives
human, mouse
Application
immunocytochemistry
western blot

Small Molecule - Blocker

Numéro du produit
Description
Espèce(s)
Mianserin hydrochloride, ,
Espèce(s)
human

Small Molecule - Mixed Agonist/Antagonist

Numéro du produit
Description
Espèce(s)
UK 14,304, ,
Espèce(s)
human
(−)-Norepinephrine, ≥98%, crystalline,
Espèce(s)
human, rat
Haloperidol, powder,
Espèce(s)
human, rat

esiRNA

Numéro du produit
Description
Espèce(s)
MISSION® esiRNA, targeting mouse Adra2c,
Espèce(s)
mouse