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Merck

ADRA2A

adrenoceptor alpha 2A

Synonymes:
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(150) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • Mouse(11551) adrenergic receptor, alpha 2a
  • Rat(25083) adrenoceptor alpha 2A
  • domestic guinea pig(100135475) adrenergic receptor, alpha 2a
  • chicken(428980) adrenergic, alpha-2A-, receptor
  • sheep(100170317) adrenoceptor alpha 2A
  • Domestic Rabbit(100009424) adrenoceptor alpha 2A
  • Zebrafish(266750) adrenergic, alpha-2A-, receptor
  • dog(486888) adrenoceptor alpha 2A
  • domestic cat(664736) adrenoceptor alpha 2A
  • sheep(101117291) adrenoceptor alpha 2A
  • naked mole-rat(101723298) adrenoceptor alpha 2A
  • cow(282135) adrenergic, alpha-2A-, receptor

Custom & Knockdown Gene Products

Small Molecule - Agonist

Numéro du produit
Description
Espèce(s)
Xylazine hydrochloride, ≥99.0% (HPLC),
Espèce(s)
human
(−)-3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine sesquihydrate, 99%,
Espèce(s)
human
Guanabenz acetate salt, powder,
Espèce(s)
human
Guanfacine hydrochloride, ≥98% (HPLC),
Espèce(s)
human
Methyldopa, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Numéro du produit
Description
Espèce(s)
1-Naphthylmethylamine, 97%,
Espèce(s)
rat
Yohimbine hydrochloride, ≥98% (HPLC), powder,
Espèce(s)
human
1,2,3,4-Tetrahydroisoquinoline, 95%,
Espèce(s)
rat, human
Idazoxan hydrochloride, ,
Espèce(s)
human
RX 821002 hydrochloride, solid, ≥98% (HPLC),
Espèce(s)
human

Antibodies

Numéro du produit
Description
Espèces réactives
Application
Anti-Adrenergic Receptor α-2A antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-ADRA2A antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
canine, human, mouse, rat
Application
ELISA
immunocytochemistry

immunofluorescence
Anti-ADRA2A antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunofluorescence

Small Molecule - Blocker

Numéro du produit
Description
Espèce(s)
Mianserin hydrochloride, ,
Espèce(s)
human

Small Molecule - Mixed Agonist/Antagonist

Numéro du produit
Description
Espèce(s)
UK 14,304, ,
Espèce(s)
human
(−)-Norepinephrine, ≥98%, crystalline,
Espèce(s)
human, rat
Haloperidol, powder,
Espèce(s)
human, rat