- β6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway.
β6 integrin induces the expression of metalloproteinase-3 and metalloproteinase-9 in colon cancer cells via ERK-ETS1 pathway.
Cancer letters (2014-08-20)
Huijie Gao, Cheng Peng, Benjia Liang, Muhammad Shahbaz, Song Liu, Ben Wang, Qi Sun, Zhengchuan Niu, Weibo Niu, Enyu Liu, Jiayong Wang, Pengfei Lin, Jian Wang, Jun Niu
PMID25135220
ABSTRACT
We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of ETS1, an important transcription factor of MMP genes. Here, we showed that β6 induced phosphorylation of ETS1 via the ERK/MAPK pathways, through which the MMP-3/MMP-9 promoters were stimulated, thereby leading to the up-regulation of MMP-3/MMP-9, and subsequent the invasion of colon cancer cells.
MATERIALS