The antibody neutralizes the biological activity of recombinant mouse MIP-3β. Using 50 times more, the antibody will neutralize the biological activity of recombinant human MIP-3β. The antibody shows 5% cross-reactivity with recombinant human MIP-3β.
Immunogen
Recombinant mouse MIP-3β, expressed in Escherichia coli.
Biochem/physiol Actions
Macrophage Inflammatory Protein-3β is a chemokine that facilitates the migration of dendritic cells and antigen-presenting cells. It interacts with specific G protein-coupled seven-transmembrane domain chemokine receptor, CCR7 and promotes interactions between T cells and dendritic cells and migration of activated B cells to lymphoid tissues.
Physical form
Lyophilized from a 0.2 μm-filtered solution in phosphate-buffered saline containing carbohydrates.
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Tumor immunotherapy aims at activating the body's own immune system to fight an existing tumor. Effective antitumor responses require tumor antigens to be presented to lymphocytes. We aimed to test the hypothesis that intratumoral administration of recombinant adenovirus encoding MIP3beta
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