IDO1
indoleamine 2,3-dioxygenase 1
Synonyms:
IDO, IDO-1, INDO
Species:
Human IDO1 (3620), Mouse Ido1 (15930), Rat Ido1 (66029), Zebrafish ido1 (571967), dog IDO1 (475574), domestic guinea pig Ido1 (100728309), naked mole-rat Ido1 (101723745), domestic cat IDO1 (101096977), cow IDO1 (506281), sheep IDO1 (100196903)
UniProtKB ID:
Gene ID:
- Human(3620) Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
- Mouse(15930) indoleamine 2,3-dioxygenase 1
- Rat(66029) indoleamine 2,3-dioxygenase 1
- Zebrafish(571967) indoleamine 2,3-dioxygenase 1
- dog(475574) indoleamine 2,3-dioxygenase 1
- domestic guinea pig(100728309) indoleamine 2,3-dioxygenase 1
- naked mole-rat(101723745) indoleamine 2,3-dioxygenase 1
- domestic cat(101096977) indoleamine 2,3-dioxygenase 1
- cow(506281) indoleamine 2,3-dioxygenase 1
- sheep(100196903) indoleamine 2,3-dioxygenase 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-IDO1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-INDO antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-IDO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab3,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-IDO1 Antibody, clone 1B17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-IDO1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunohistochemistry
Proteins
Product Number
Description
Species